See our new paper describing the role of Drp1 SUMOylation by MAPL/MUL1 in stabilizing ER/mitochondrial contacts during cell death. This stabilization maintains the mitochondria in a constricted state downstream of Bax activation. These constricted contacts are required for inner membrane cristae remodelling and cytochrome c release, which requires calcium influx from the ER. Congrats to all authors for this exciting work!!
Mol Cell. 2015 Sep 17;59(6):941-55. MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death. Prudent J, Zunino R, Sugiura A, Mattie S, Shore GC, McBride HM