New paper in Molecular Cell

New paper in Molecular Cell

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See our new paper describing the role of Drp1 SUMOylation by MAPL/MUL1 in stabilizing ER/mitochondrial contacts during cell death.  This stabilization maintains the mitochondria in a constricted state downstream of Bax activation.  These constricted contacts are required for inner membrane cristae remodelling and cytochrome c release, which requires calcium influx from the ER. Congrats to all authors for this exciting work!!
Mol Cell. 2015 Sep 17;59(6):941-55. MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death. Prudent J, Zunino R, Sugiura A, Mattie S, Shore GC, McBride HM